Wittrup, K Dane: search on Z-Library

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1

Yeast surface display for screening combinatorial polypeptide libraries

Boder, Eric T., Wittrup, K. Dane

Journal:

Nature Biotechnology

Year:

1997

File:

PDF, 1.37 MB

1997

2

A mechanistic compartmental model for total antibody uptake in tumors

Greg M. Thurber, K. Dane Wittrup

Journal:

Journal of Theoretical Biology

Year:

2012

Language:

english

File:

PDF, 805 KB

english, 2012

3

Purification of common light chain IgG-like bispecific antibodies using highly linear pH gradients

Sharkey, Beth, Pudi, Sarat, Wallace Moyer, Ian, Zhong, Lihui, Prinz, Bianka, Baruah, Hemanta, Lynaugh, Heather, Kumar, Sampath, Wittrup, K. Dane, Nett, Juergen H.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.83 MB

english, 2017

4

Protein engineering by cell-surface display

Journal:

Current Opinion in Biotechnology

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

5

Isolating and engineering human antibodies using yeast surface display

Chao, Ginger, Lau, Wai L, Hackel, Benjamin J, Sazinsky, Stephen L, Lippow, Shaun M, Wittrup, K Dane

Journal:

Nature Protocols

Year:

2006

Language:

english

File:

PDF, 464 KB

english, 2006

6

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

Jamie B. Spangler, Jason R. Neil, Sivan Abramovitch, Yosef Yarden, Forest M. White, Douglas A. Lauffenburger, K. Dane Wittrup and John Kuriyan

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

7

Artificial Anti-Tumor Opsonizing Proteins with Fibronectin Scaffolds Engineered for Specificity to each of the Murine FcγR Types

Chen, Tiffany F., Li, Kevin K., Zhu, Eric F., Opel, Cary F., Kauke, Monique J., Kim, Heeyoon, Atolia, Eta, Dane Wittrup, K.

Journal:

Journal of Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

8

Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease

Hwang, Soyoon Sarah, Chan, Hon, Sorci, Mirco, Van Deventer, James, Wittrup, Dane, Belfort, Georges, Walt, David

Journal:

Analytical Biochemistry

Year:

2018

Language:

english

File:

PDF, 1.52 MB

english, 2018

9

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Wang, Shenshen, Mata-Fink, Jordi, Kriegsman, Barry, Hanson, Melissa, Irvine, Darrell J., Eisen, Herman N., Burton, Dennis R., Wittrup, K. Dane, Kardar, Mehran, Chakraborty, Arup K.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

10

Quantitative Screening of Yeast Surface-Displayed Polypeptide Libraries by Magnetic Bead Capture

Yik A. Yeung, K. Dane Wittrup

Journal:

Biotechnology Progress

Year:

2002

Language:

english

File:

PDF, 123 KB

english, 2002

11

Monovalent, reduced-size quantum dots for imaging receptors on living cells

Howarth, Mark, Liu, Wenhao, Puthenveetil, Sujiet, Zheng, Yi, Marshall, Lisa F, Schmidt, Michael M, Wittrup, K Dane, Bawendi, Moungi G, Ting, Alice Y

Journal:

Year:

2008

Language:

english

File:

PDF, 243 KB

english, 2008

12

Development of a Human Light Chain Variable Domain (VL) Intracellular Antibody Specific for the Amino Terminus of Huntingtin via Yeast Surface Display

David W. Colby, Payal Garg, Tina Holden, Ginger Chao, Jack M. Webster, Anne Messer, Vernon M. Ingram, K. Dane Wittrup

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 578 KB

english, 2004

13

Dose dependence of intratumoral perivascular distribution of monoclonal antibodies

John J. Rhoden, Karl Dane Wittrup

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 322 KB

english, 2012

14

Factors determining antibody distribution in tumors

Greg M. Thurber, Michael M. Schmidt, K. Dane Wittrup

Journal:

Trends in Pharmacological Sciences

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

15

High-Affinity CD25-Binding IL-2 Mutants Potently Stimulate Persistent T Cell Growth †

Rao, Balaji M., Driver, Ian, Lauffenburger, Douglas A., Wittrup, K. Dane

Journal:

Year:

2005

Language:

english

File:

PDF, 103 KB

english, 2005

16

Purification and Functional Characterization of a Chaperone from Methanococcus jannaschii

Jean M. Kowalski, Robert M. Kelly, Jordan Konisky, Douglas S. Clark, K. Dane Wittrup

Journal:

Systematic and Applied Microbiology

Year:

1998

Language:

english

File:

PDF, 2.15 MB

english, 1998

17

Target-independent variable region mediated effects on antibody clearance can be FcRn independent

Kelly, Ryan L., Yu, Yao, Sun, Tingwan, Caffry, Isabelle, Lynaugh, Heather, Brown, Michael, Jain, Tushar, Xu, Yingda, Wittrup, K. Dane

Journal:

Year:

2016

Language:

english

File:

PDF, 1.25 MB

english, 2016

18

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1)

Singh, Aman P., Maass, Katie F., Betts, Alison M., Wittrup, K. Dane, Kulkarni, Chethana, King, Lindsay E., Khot, Antari, Shah, Dhaval K.

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 1017 KB

english, 2016

19

Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments

Jennifer R. Cochran, Yong-Sung Kim, Mark J. Olsen, Rashna Bhandari, K.Dane Wittrup

Journal:

Journal of Immunological Methods

Year:

2004

Language:

english

File:

PDF, 512 KB

english, 2004

20

[IEEE 2014 40th Annual Northeast Bioengineering Conference (NEBEC) - Boston, MA, USA (2014.4.25-2014.4.27)] 2014 40th Annual Northeast Bioengineering Conference (NEBEC) - A yeast-based approach to the development of antibodies targeting cancer-associated fibroblasts

Van Deventer, James A., Dane Wittrup, Karl, Rajan, Sarav, Sidhu, Sachdev S.

Year:

2014

Language:

english

File:

PDF, 1.77 MB

english, 2014

21

Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells

Liu, David V., Maier, Lisa M., Hafler, David A., Wittrup, K. Dane

Journal:

Journal of Immunotherapy

Year:

2009

Language:

english

File:

PDF, 970 KB

english, 2009

22

Glutathione excretion in response to heterologous protein secretion in saccharomyces cerevisiae

Sarah J. Bannister, K. Dane Wittrup

Journal:

Biotechnology and Bioengineering

Year:

2000

Language:

english

File:

PDF, 210 KB

english, 2000

23

Disulfide bond formation and eukaryotic secretory productivity

Journal:

Current Opinion in Biotechnology

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

24

Stochastic kinetics of intracellular huntingtin aggregate formation

Colby, David W, Cassady, John P, Lin, Grace C, Ingram, Vernon M, Wittrup, K Dane

Journal:

Nature Chemical Biology

Year:

2006

Language:

english

File:

PDF, 230 KB

english, 2006

25

Preface

Robert M. Kelly, K. Dane Wittrup, Subhash Karkare

Journal:

Annals of the New York Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 79 KB

english, 1994

26

Antibody-Mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery

Yang, Nicole J., Liu, David V., Sklaviadis, Demetra, Gui, Dan Y., Vander Heiden, Matthew G., Wittrup, K. Dane

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 892 KB

english, 2015

27

10.1038/80223

Wittrup, K. Dane

Journal:

Nature Biotechnology

Year:

2000

Language:

english

File:

PDF, 87 KB

english, 2000

28

[Methods in Enzymology] Protein Engineering for Therapeutics, Part B Volume 503 || Preface

Wittrup, K. Dane

Year:

2012

Language:

english

File:

PDF, 21 KB

english, 2012

29

Contrasting secretory processing of simultaneously expressed heterologous proteins in Saccharomyces cerevisiae

Andy Rakestraw, K. Dane Wittrup

Journal:

Biotechnology and Bioengineering

Year:

2006

Language:

english

File:

PDF, 265 KB

english, 2006

30

A small-molecule catalyst of protein folding in vitro and in vivo

Kenneth J Woycechowsky, K Dane Wittrup, Ronald T Raines

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

31

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors

de Picciotto, Seymour, Imperiali, Barbara, Griffith, Linda G., Wittrup, K. Dane

Journal:

Analytical Biochemistry

Year:

2014

Language:

english

File:

PDF, 1.80 MB

english, 2014

32

Secretion Efficiency in Saccharomyces cerevisiae of Bovine Pancreatic Trypsin Inhibitor Mutants Lacking Disulfide Bonds Is Correlated with Thermodynamic Stability †

Kowalski, Jean M., Parekh, Rajesh N., Wittrup, K. Dane

Journal:

Year:

1998

Language:

english

File:

PDF, 95 KB

english, 1998

33

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

Tzeng, Alice, Kwan, Byron H., Opel, Cary F., Navaratna, Tejas, Wittrup, K. Dane

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

34

Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in Saccharomyces cerevisiae

J. Andy Rakestraw, Stephen L. Sazinsky, Andrea Piatesi, Eugene Antipov, K. Dane Wittrup

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 474 KB

english, 2009

35

An Integrating Vector for Tunable, High Copy, Stable Integration into the Dispersed Ty δ Sites of Saccharomyces cerevisiae

Rajesh N. Parekh, Mark R. Shaw, K. Dane Wittrup

Journal:

Biotechnology Progress

Year:

1996

Language:

english

File:

PDF, 196 KB

english, 1996

36

A Flow Cytometric Assay for Screening Improved Heterologous Protein Secretion in Yeast

J. Andy Rakestraw, Angelin R. Baskaran, K. Dane Wittrup

Journal:

Biotechnology Progress

Year:

2006

Language:

english

File:

PDF, 371 KB

english, 2006

37

Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression

Jamie B. Spangler, Mandana T. Manzari, Elizabeth K. Rosalia, Tiffany F. Chen, K. Dane Wittrup

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

38

Expression of the 180-kD Ribosome Receptor Induces Membrane Proliferation and Increased Secretory Activity in Yeast

Frank Becker, Laura Block-Alper, Gerald Nakamura, Josephine Harada, K. Dane Wittrup and David I. Meyer

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 3.63 MB

english, 1999

39

Jay Bailey as mentor—The students' perspective

Kenneth F. Reardon, Kelvin H. Lee, K. Dane Wittrup, Vassily Hatzimanikatis

Journal:

Biotechnology and Bioengineering

Year:

2002

Language:

english

File:

PDF, 341 KB

english, 2002

40

Propagation of an amplifiable recombinant plasmid in Saccharomyces cerevisiae: flow cytometry studies and segregated modeling

K. Dane Wittrup, James E. Bailey, Barry Ratzkin, Avantika Patel

Journal:

Biotechnology and Bioengineering

Year:

1990

Language:

english

File:

PDF, 1003 KB

english, 1990

41

Structural Model of the mAb 806-EGFR Complex Using Computational Docking followed by Computational and Experimental Mutagenesis

Arvind Sivasubramanian, Ginger Chao, Heather M. Pressler, K. Dane Wittrup, Jeffrey J. Gray

Journal:

Year:

2006

Language:

english

File:

PDF, 687 KB

english, 2006

42

A Disulfide-Free Single-Domain VL Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition

André Schiefner, Lorenz Chatwell, Jana Körner, Irmgard Neumaier, David W. Colby, Rudolf Volkmer, K. Dane Wittrup, Arne Skerra

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 2.15 MB

english, 2011

43

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-Neutralized Hyperthermostable Sso7d Scaffold Library

Traxlmayr, Michael W., Kiefer, Jonathan D., Srinivas, Raja R., Lobner, Elisabeth, Tisdale, Alison W., Mehta, Naveen K., Yang, Nicole J., Tidor, Bruce, Wittrup, K. Dane

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.61 MB

english, 2016

44

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

Yang, Nicole J., Kauke, Monique J., Sun, Fangdi, Yang, Lucy F., Maass, Katie F., Traxlmayr, Michael W., Yu, Yao, Xu, Yingda, Langer, Robert S., Anderson, Daniel G., Wittrup, K. Dane

Journal:

Nucleic Acids Research

Year:

2017

Language:

english

File:

PDF, 2.91 MB

english, 2017

45

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Angelini, Alessandro, Miyabe, Yoshishige, Newsted, Daniel, Kwan, Byron H., Miyabe, Chie, Kelly, Ryan L., Jamy, Misha N., Luster, Andrew D., Wittrup, K. Dane

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.57 MB

english, 2018

46

Chaperone proteins as single component reagents to assess antibody nonspecificity

Kelly, Ryan L., Geoghegan, James C., Feldman, Jared, Jain, Tushar, Kauke, Monique, Le, Doris, Zhao, Jessie, Wittrup, K. Dane

Journal:

Year:

2017

Language:

english

File:

PDF, 1.01 MB

english, 2017

47

A33 antigen displays persistent surface expression

Margaret E. Ackerman, Cecile Chalouni, Michael M. Schmidt, Vivek V. Raman, Gerd Ritter, Lloyd J. Old, Ira Mellman, K. Dane Wittrup

Journal:

Cancer Immunology, Immunotherapy

Year:

2008

Language:

english

File:

PDF, 621 KB

english, 2008

48

Biosynthetic polypeptide libraries

Eric V Shusta, Jennifer VanAntwerp, K Dane Wittrup

Journal:

Current Opinion in Biotechnology

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

49

Corrigendum to: “Fine Epitope Mapping of anti-Epidermal Growth Factor Receptor Antibodies Through Random Mutagenesis and Yeast Surface Display” [J. Mol. Biol. (2004) 342, 539–550]

Ginger Chao, Jennifer R. Cochran, K. Dane Wittrup

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 45 KB

english, 2005

50

Stability and CDR Composition Biases Enrich Binder Functionality Landscapes

Benjamin J. Hackel, Margaret E. Ackerman, Shanshan W. Howland, K. Dane Wittrup

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 891 KB

english, 2010

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